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Paracetamol er en sikker mulighed for reasonable smerter og betragtes som mindre risikabel end opioider. Smertelindring udvikler sig konstant for at finde sikrere metoder, der forbedrer livskvaliteten uden risikoen for afhængighed.Generelt har medicin fra den tricykliske gruppe af antidepressiva større smertestillende effekt ved lavere dosis clos
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